AskDefine | Define haploid

Dictionary Definition

haploid adj : of a cell or organism having a single set of chromosomes [syn: haploidic, monoploid] [ant: diploid, polyploid] n : (genetics) an organism or cell having only one complete set of chromosomes

User Contributed Dictionary



  1. Of a cell having a single set of unpaired chromosomes, such as a gamete.

Derived terms


haploid (plural haploids)
  1. A cell which is haploid; an organism, such as a fungus, with haploid cells.

Extensive Definition

"Haplo" redirects here. For the fictional character, see The Death Gate Cycle.
Ploidy is the number of homologous sets of chromosomes in a biological cell. The ploidy of cells can vary within an organism. In humans, most cells are diploid (containing one set of chromosomes from each parent), but sex cells (sperm and egg) are haploid. In contrast, tetraploidy (four sets of chromosomes) is a type of polyploidy and is common in plants, and not uncommon in amphibians, reptiles, and various species of insects.
The number of chromosomes in one of the mutually-homologous sets is called the monoploid number (x). This is the same number for every set in every cell of a given organism.
Euploidy is the state of a cell or organism having an integral multiple of the monoploid number, possibly excluding the sex-determining chromosomes. For example, a human cell has 46 chromosomes, which is an integer multiple of the monoploid number, 23. A human with abnormal, but integral, multiples of this full set (e.g. 69 chromosomes) would also be considered as euploid. Aneuploidy is the state of not having euploidy. In humans, examples include having a single extra chromosome (such as Down syndrome), or missing a chromosome (such as Turner syndrome). Aneuploidy is not normally considered -ploidy but -somy, such as trisomy or monosomy.

Haploid and Monoploid

The haploid number is the number of chromosomes in a gamete of an individual. This is distinct from the monoploid number which is the number of unique chromosomes in a single complete set.
In humans, the monoploid number (x) equals the haploid number (the number in a gamete, n), that is, x = n = 23. In some species (especially plants), these numbers differ. Commercial common wheat is an allopolyploid with six sets of chromosomes, two sets coming originally from each of three different species, with six copies of chromosomes in each cell. The gametes of common wheat are considered as haploid since they contain half the genetic information of somatic cells, but are not monoploid as they still contain three complete sets of chromosomes from the original three different species (n = 3x).
Most fungi and a few algae are monoploid organisms, and male bees, wasps, and ants are haploid because of the way they develop from unfertilized, haploid eggs. The Australian bulldog ant, Myrmecia pilosula, a haplodiploid species has n = 1, the lowest known (and lowest theoretically possible) n. A monoploid cell is likely to be identical to the cell it was copied from however in haploid cells one of two differing copies of the same chromosome is in the haploid set.
Plants and some algae switch between a haploid and a diploid or polyploid state, with one of the stages emphasized over the other. This is called alternation of generations. Most diploid organisms produce monoploid sex cells that can combine to form a diploid zygote, for example animals are primarily diploid but produce monoploid gametes. During meiosis, germ cell precursors have their number of chromosomes halved by randomly "choosing" one homologue, resulting in haploid germ cells (sperm and ovum).


Diploid cells have two homologous copies of each chromosome, usually one from the mother and one from the father. The exact number of chromosomes may be one or two different from the 2 number yet the cell may still be classified as diploid (although with aneuploidy). Nearly all mammals are diploid organisms, although all individuals have some small fraction of cells that display polyploidy. Human diploid cells have 46 chromosomes and human haploid gametes (egg and sperm) have 23 chromosomes.
Retroviruses that contain two copies of their RNA genome in each viral particle are also said to be diploid. Examples include human foamy virus, human T-lymphotropic virus, and HIV.


Haploidisation (haploidization) is the process of creating a haploid cell (usually from a diploid cell).
A laboratory procedure called haploidisation forces a normal cell to expel half of its chromosomal complement. In mammals this renders this cell chromosomally equal to sperm or egg. This was one of the procedures used by Japanese researchers to produce Kaguya, a fatherless mouse.
Haploidisation sometimes occurs in plants when meiotically reduced cells (usually egg cells) develop by parthenogenesis.


Polyploidy is the state where all cells have multiple pairs of chromosomes beyond the basic set. These may be from the same species or from closely related species. In the latter case these are known as allopolyploids, amphidiploids or allotetraploids. Allopolyploids can be formed from the hybridisation of two separate species followed by their subsequent chromosome doubling. A good example is the so-called Brassica triangle where three different parent species have hybridized in each pair combination to form three different allopolyploid species. Polyploid plants are probably most often formed from the pairing of meiotically unreduced gametes (Ramsey and Schemske, 2002).
Polyploidy occurs commonly in plants, but rarely in animals. Even in diploid organisms many somatic cells are polyploid due to a process called endoreduplication where duplication of the genome occurs without mitosis (cell division).
The extreme in polyploidy occurs in the fern-ally genus Ophioglossum, the adder's-tongues, in which polyploidy results in chromosome counts in the hundreds, or in at least one case, well over one thousand. Interestingly, these plants seem to have simplified structures in their phenotype.

Variable or indefinite ploidy

Depending on growth conditions, prokaryotes such as bacteria may have a chromosome copy number of 1 to 4, and that number is commonly fractional, counting portions of the chromosome partly replicated at a given time. This is because under logarithmic growth conditions the cells are able to replicate their DNA faster than they can divide.


Mixoploidy refers to the presence of two cell lines, one diploid and one polyploid. Though polyploidy in humans is not viable, mixoploidy has been found in live adults and children. There are two types: diploid-triploid mixoploidy, in which some cells have 46 chromosomes and some have 69, and diploid-tetraploid mixoploidy, in which some cells have 46 and some have 92 chromosomes.

Dihaploidy and Polyhaploidy

Dihaploid and polyhaploid cells are formed by haploidisation of polyploids, i.e., by halving the chromosome constitution.
Dihaploids (which are diploid) are important for selective breeding of tetraploid crop plants (notably potatoes), because selection is faster with diploids than with tetraploids. Tetraploids can be reconstituted from the diploids, for example by somatic fusion.
The term “dihaploid” was coined by Bender (1963) to combine in one word the number of genome copies (diploid) and their origin (haploid). The term is well established in this original sense (e.g., Nogler 1984; Pehu 1996), but it has also been used for doubled monoploids or doubled haploids, which are homozygous and used for genetic research (Sprague et al, 1960).


  • Bender, K. 1963. “Über die Erzeugung und Enstehung dihaploider Pflanzen bei Solanum tuberosum”. Zeitschrift für Pflanzenzüchtung 50: 141–166.
  • Griffiths, A. J. et al. 2000. An introduction to genetic analysis, 7th ed. W. H. Freeman, New York ISBN 0-7167-3520-2
  • Nogler, G.A. 1984. Gametophytic apomixis. In Embryology of angiosperms. Edited by B.M. Johri. Springer, Berlin, Germany. pp. 475–518.
  • Pehu, E. 1996. The current status of knowledge on the cellular biology of potato. Potato Research 39: 429–435.
  • Ramsey, J., and Schemske, D.W. 2002. "Neopolyploidy in flowering plants". Annual Review of Ecology and Systematics 33: 589–639.
  • Sprague, G.F., Russell, W.A., and Penny, L.H. 1960. Mutations affecting quantitative traits in the selfed progeny of double monoploid maize stocks. Genetics 45(7): 855–866.
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